The Commonwealth of Pennsylvania is home to an enormous amount of American history, the sixth-largest economy in the nation, and two major metropolitan areas. On the eastern seaboard, Philadelphia is the sixth-largest city in the country and is historically, culturally, and economically important given that it is just a short commute away from both New York City and Washington, D.C. due to its position in the center of the northeastern megalopolis. Over on the western end of the state is Pittsburgh, which has long been a center of manufacturing, culture, and academia. In between Pennsylvania’s two prominent cities is a massive, mostly rural expanse of land that features diverse geography and culture, including plenty of agriculture as well as small cities. As is the case in most U.S. states, neither Pennsylvania’s urban centers nor its rural areas are immune from the scourge of the drug epidemic.